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Boc-Val-Dil-Dap-OH 是一種可降解 (cleavable) 的 ADC 連接橋，用于抗體藥物結(jié)合物 (ADCs) 的合成

理想情況下，應(yīng)在ADC開發(fā)和表征的早期階段開發(fā)用于非臨床PK生物學(xué)分析的測定方法。與平均DAR標(biāo)準(zhǔn)相比，可以通過測定富集或純化的藥物抗體比率（DAR）分?jǐn)?shù)的回收率來進(jìn)行分析評(píng)估，以確保不同的分析形式均等地回收藥物。如果無法進(jìn)行此分析，則對(duì)于生物分析方法的設(shè)計(jì)，ADC的作用機(jī)理，靶向的**抗原，接頭的類型，藥物抗體比率，細(xì)胞毒性藥物等的詳細(xì)信息是必需的。除了LBA方法外，親水相互作用色譜（HILIC），HPLC和LC-MS還用于定量ADC。

ADC相關(guān)資料：

Boc-Val-Dil-Dap-OH

Boc-Val-Dil-Dap-Phe-OMe

Boc-Val-Dil-Dap-Doe

Boc-Val-Dil-Dap-Nrp

Boc-N-Me-Val-Val-Dil-Dap-OH

Tubulysin IM-1

Tubulysin IM-2

Tubulysin IM-3

Duocarmycin SA  152785-82-5

Duocarmycin TM

Duocarmycin MA

Duocarmycin DM

Nemorubicin 108852-90-0

PNU-159682 202350-68-3

Calicheamicin g1 108212-75-5

Acetyl-Calicheamicin g1 108212-76-6

a-Amanitin 23109-05-9

PBD-dimer 1222490-34-7

OSu-Glu-vc-PAB-MMAE

SMCC-DM1

SPDB-DM4

OSu-PEG4-vc-PAB-DMEA
Duocarmycin SA

Mylotarg-linker

OSu-Glu-vc-PAB-MMAD

Sulfo-SPDB-DM4

IMGN779-linker

OSu-PEG4-vc-PAB-DMEA

Duocarmycin TM

OSu-PEG4-vc-PAB-DMEA
Duocarmycin DM

MC-vc-PAB-MMAE

MC-MMAF

MC-DM1

MC-MMD-10

MA-PEG4-vc-PAB-DMEA-duocarmycin SA

MC-vc-PAB-C6-a-amanitin

MC-cleavable-linker-a-amanitin

MC-vc-PAB-DMEA-(PEG2)-duocarmycin SA

MC-vc-PAB-Tubulysin M

MC-va-PAB-MMAD

MA-PEG4-VC-PAB-DMAE-PNU159682

MA-PEG4-VA-PBD

MC-vc-PAB-MMAF

MC-vc-PAB-MMAD

MC-vc-PAB-Auristatin 0101

MA-PEG8-VA-PAB-SG3199

CL2A-SN 38

MC-GGFG-DX8951

MEDI4276_linker payload

MA-PEG4-vc-PAB-DMEA-duocarmycin TM

MC-vc-PAB-(PEG2)-duocarmycin TM

MA-PEG4-vc-PAB-DMEA-duocarmycin DM

MC-vc-PAB-(PEG2)-duocarmycin DM

DGN549

MPB-vc-PAB-MMAE

MPB-MMAF

DBCO-PEG4-vc-PAB-MMAE

DBCO-PEG4-MMAF

DBCO-PEG4-Ahx-DM1

DBCO-PEG4-vc-PAB-Duocarmycin SA

DBCO-PEG4-vc-PAB-(PEG2)-Duocarmycin SA

DBCO-PEG4-VA-PBD

DBCO-PEG4-vc-PAB-MMAF

DBCO-PEG4-vc-PAB-MMAD

DBCO-PEG4-vc-PAB-Duocarmycin TM

DBCO-PEG4-vc-PAB-(PEG2)-Duocarmycin TM

DBCO-PEG4-vc-PAB-Duocarmycin DM

DBCO-PEG4-vc-PAB-(PEG2)-Duocarmycin DM

DBCO-PEG4-VC-PAB-DMAE-PNU159682

DBCO-PEG4-DMAE-PNU159682

DBCO-PEG4-GGFG-DX8951

DBCO-PEG4-vc-PAB-Ahx-DM1

DBCO-PEG8-VA-PAB-SG3199

Gly3-vc-PAB-MMAE

Gly3-MMAF

Gly5-Ahx-DM1

PNU159682-EDA-Gly3

ADC pre-screening kit A

Protein A-DM1

Protein A-MMAE

Protein A-MMAF

Protein A-Duocarmycin

Protein A-Calicheamicin

Protein A-PBD

ADC pre-screening kit G

Protein G-DM1

Protein G-MMAE

Protein G-MMAF

Protein G-Duocarmycin

Protein G-Amanitin

Protein G-Amanitin

Rabbit Anti-vc-PAB-MMAE pAb

Mouse Anti-vc-PAB-MMAE mAb (B11F11)

Rabbit Anti-MMAF pAb

Mouse Anti-MMAF mAb (F3B11)

Mouse Anti-MMAE / F mAb (B12A2)

Mouse Anti-MMAE /F mAb (C12A1)

Rabbit Anti-DM1/4 pAb

Mouse Anti-DM1/4 mAb (F1D5)

Mouse Anti-DM1/4 mAb (G2F3)

Rabbit Anti-Calicheamicin pAb

Mouse Anti-Calicheamicin mAb (B1G9)

Mouse Anti-Calicheamicin mAb (C1F12)

Rabbit Anti-Duocarmycin pAb 

Mouse Anti-Duocarmycin mAb (E11A1)

Mouse Anti-Duocarmycin mAb (H7A9)

Mouse Anti-Duocarmycin mAb (E6B3) 

Rabbit Anti-PNU-159682 pAb

Mouse Anti-PNU-159682 mAb (F7F2)

Mouse Anti-PNU-159682 mAb (C1E3)

Mouse Anti-PNU-159682 mAb (D12H11)

Rabbit Anti-Amanitin pAb

Mouse Anti-Amanitin mAb (H3E1)

Mouse Anti-Amanitin mAb (H12D6)

Mouse Anti-Amanitin mAb (C2C4)

Rabbit Anti-SN38 pAb

Mouse Anti-SN38 mAb (10F11A9D6)

Mouse Anti-SN38 mAb (8E10F12F3)

Mouse Anti-SN38 mAb (8E10A4A1)

Rabbit Anti-PBD SG3199 pAb

Mouse Anti-PBD SG3199 (7H6H9A6) mAb

Mouse Anti-PBD SG3199 (8G2H12A9) mAb

Mouse Anti-PBD SG3199 (8B3D12G1) mAb